Coronary Artery Research Paper Hbs Business Plan
This paper presents a secondary post hoc analysis of the SCOT-HEART study.
In brief, 4,146 patients who attended the cardiology outpatient clinic were randomized to standard care alone or standard care plus coronary CTA, and were followed up for symptoms, management, and outcomes.
CAD happens when the arteries that supply blood to heart muscle become hardened and narrowed.
In the SCOT-HEART (Scottish COmputed Tomography of the HEART) prospective, multicenter, randomized controlled trial of patients with stable chest pain, the addition of coronary CTA to routine care led to improved diagnostic certainty and patient care that ultimately reduced the rate of coronary heart disease death or nonfatal myocardial infarction (6–8).Heart failure means the heart can't pump blood well to the rest of the body.Arrhythmias are changes in the normal beating rhythm of the heart.See our disclaimer about external links and our quality guidelines.Investigators sought to determine whether percutaneous coronary intervention with drug-coated balloons is a better treatment option for coronary artery lesions than percutaneous coronary intervention with bare-metal stents.In contrast, noninvasive imaging with coronary computed tomography angiography (CTA) has the ability to provide precise structural information of the coronary artery wall, and can assess for the presence and constituents of atherosclerotic plaque even in the absence of flow-limiting disease.Pathological studies in patients with myocardial infarction have identified an association between plaque rupture and adverse plaque characteristics that includes positive remodeling, a large necrotic core, microcalcification, and a thin fibrous cap (1).Most heart attacks happen when a blood clot suddenly cuts off the hearts' blood supply, causing permanent heart damage.Over time, CAD can also weaken the heart muscle and contribute to heart failure and arrhythmias.Accepting the NEJM cookie is necessary to use the website.Methods In this SCOT-HEART (Scottish COmputed Tomography of the HEART Trial) post hoc analysis, the presence of adverse plaque (positive remodeling or low attenuation plaque), obstructive disease, and coronary artery calcification within 15 coronary segments was assessed on coronary computed tomography angiography of 1,769 patients who were followed-up for 5 years.